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Long-term hyperglycemia promotes renin and angiotensin II synthesis in mesangial cells, leading to elevated glomerular capillary pressure and permeability, which are key components in the development of proteinuria

If your hemoglobin A1C begins rising after switching, discuss with your provider whether adjusting other diabetes medications or returning to tirzepatide makes sense

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Wegovy is a semaglutide injection showing up to 14.9% body weight reduction, while Zepbound offers even greater efficacy at about 20.9% weight loss in trials