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Much of the long-term safety data also comes from early versions of the drugs

That includes endocrinologists

Rare serious risks include pancreatitis and gallbladder issues

However, RAS inhibition has not yet been found to prevent kidney disease among those with type 1 diabetes, normal blood pressure and without albuminuria, and also does not prevent the progression of histological changes associated with DKD at the early stage of disease [22]
Yes, GLP-1 peptides travel to the pancreas when your gut releases them after a meal but also to the brain, the heart, the kidneys, the gut lining, and the immune system

Adherence challenges are not unique to GLP-1s
