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Despite lower efficacy and tolerability shown by nasally administered PYY agonists in early studies, long-acting subcutaneous PYY receptor agonists such as PYY 1875 are undergoing early-phase clinical trials to evaluate their safety and effectiveness as monotherapy or in combination with GLP-1 receptor agonists for the treatment of obesity

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So when people either engage in repeated dieting or in use of one of these drugs, it has to be either a lifelong change in diet and exercise habits, or a lifelong commitment to take one of these drugs

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References: The Microbiome Connection: Your Guide to IBS, SIBO, and Low-Fermentation Eating, page 78

Improved Eating Behavior: Reduces the urge to overeat, snack between meals, or engage in emotional eating