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Estrogens help maintain muscle strength in women by preserving muscle mass and keeping the proteins responsible for muscle contractions healthy

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and no role in the decision to submit the manuscript for publication

In addition, in the EMPEROR-reduced trial, enrolling about 3700 patients affected by heart failure with reduced ejection fraction (HFrEF), empagliflozin significantly reduced the risk of heart failure hospitalization and decreased total hospitalization for HF regardless of the presence of diabetes or baseline levels of glycohemoglobin (HbA1c) (49, 50)

Conclusion The recent dramatic success of GLP-1RAs in weight management and the reports of numerous beneficial pleiotropic effects of this class of drugs highlight the immense potential for repurposing drugs to extend lifespan and markets of drugs

Collectively, the results discussed above could be interpreted to suggest that conditions likely to result in -cell stress, such as obesity, hyperglycaemia, and inflammation, activate compensatory responses in an attempt to improve -cell function and survival