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In people with T2D, SUSTAIN-6 revealed increased diabetic-retinopathy complications with semaglutide, primarily in subjects with pre-existing retinopathy and rapid HbA1c reduction 45,46

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Usually taken by self-administered injection, these medications mimic the action of the natural hormone GLP-1 (glucagon-like peptide-1), which is produced in the gut and plays important roles in appetite regulation and glucose metabolism

Individual variation matters Clinical trial averages mask enormous individual variation

This can help prevent rapid spikes and crashes in blood sugar levels