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[2] Central nervous system effects appear potentially relevant to understanding how these medications might influence binge eating patterns

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GLP-1R is expressed in dorsal root ganglion (DRG) neurons 40 and could explain the potential direct effect on pain in OA since DRG neuron endings are present in the synovium 41

[46] This activation reduces the production of reactive oxygen species (ROS) and mitigates endoplasmic reticulum (ER) stress