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The tipping point might be changing patient perception to improve adherence since new prescriptions apparently are proving to be not so easy to generate

Future research must validate and challenge our metaanalysis findings, especially because LOE is a growing global challenge that is potentially amenable to preventative therapies

Genet Med Off J Am Coll Med Genet

When the TLR receptor binds to its ligand, it activates downstream signaling pathways that trigger the production of a variety of signaling molecules and cytokines, which ultimately leads to an inflammatory response and the activation of immune cells

That information helps the reviewing clinician make an appropriate determination

2017;12(11):e0187365