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Your body is unlikely to tolerate a high dose immediately, which could lead to side effects and might even make you want to stop the treatment altogether

To address affordability, Eli Lilly introduced LillyDirect on December 1, 2025, offering lower-cost single-dose vials of Zepbound

It is generally prescribed when other diabetes treatments, like metformin, have no effect

If four or more days have passed since your missed dose, skip it entirely and resume your regular weekly schedule to avoid increased gastrointestinal side effects

Individual weigh-ins do not

Patients in the semaglutide or tirzepatide group had an increased incidence of other optic disc disorders, but this difference was not statistically significant (Figure 2)