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Preclinical evidence is limited

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GLP-1 RAs, such as exenatide and lixisenatide, have shown benefits in addressing the pathology of PD in animal studies and phase II clinical trials, halting progression and delaying worsening of symptoms

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In one clinical trial, a once-weekly 2-mg dose of exenatide was compared with a twice-daily 10-g dose of exenatide

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However, this could reflect differences in the TMD of GLP-1R and GCGR and their intrinsic ability to activate G protein in the absence of agonist, independent of the ECD

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