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Weight regain after semaglutide discontinuation occurs in many patients, but maintenance is achievable with continued medication, lifestyle adherence, and provider oversight

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The observations that GLP-1 receptor agonists exert anti-inflammatory actions in preclinical studies, taken together with case reports linking improvements in psoriasis with GLP-1 receptor agonist therapy, illustrates the emerging clinical implications of non-classical anti-inflammatory actions of incretin-based therapeutics.
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