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NICE recommendations for GLP-1 therapy include: For type 2 diabetes (NICE NG28): GLP-1 therapy should only be continued if there is a beneficial metabolic response (HbA1c reduction of 11 mmol/mol [1.0%] and weight loss of 3% of initial body weight at 6 months)
& Goldstein, B

doi: 10.1111/j.1464-5491.2012.03624.x

Critics argue even low doses could increase infection susceptibility in vulnerable people

This is why it is important to understand what additional weight management efforts patients pursue in real-world settings after discontinuing semaglutide or tirzepatide, and whether long-term weight changes after discontinuation follow the patterns reported in randomized clinical trials. Hamlet Gasoyan, DS, PhD, MPH According to the researchers, a potential reason for the difference may be that people often continue their treatment journey in other ways