glp 1 agonist anesthesia How should we approach patients on GLP-1 agonists? Check out this excellent editorial from Dr. Girish Joshi, "Clarifying the Guidelines and Decoding the Enigma: Strategies for Anesthetic Management of Patients on Glucagon-Like Outpatient Sedation Basics for Patients

2025;48(Supplement1):S181206

132 Glutamate receptors, including the amino-3-hydroxy-5-methyl-4-isoxazolepro-pionicacid (AMPA) and N-methyl-D-aspartate (NMDA) receptors, mediate excitatory synaptic transmission in the CNS, and its expression in the postsynaptic membrane is associated with LTP and LTD and is involved in the regulation of learning and memory activities

Within the brain, agonism of GLP-1 could enhance cognitive function and diminish neuroinflammation and potentially provide a protective effect against diseases that are NDs, including Alzheimers disease and Parkinsons disease

This would be in line with a recent propensity-score matched cohort study by our laboratory, which observed that semaglutide was associated with reduced cognitive deficit and nicotine misuse when compared against three other antidiabetic medications 227

The DPP-4 inhibitor linagliptin restores -cell function and survival in human isolated islets through GLP-1 stabilization

Lifestyle Recommendations Exercise regularly : Aim for a combination of cardio and strength training exercises