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Your body adapted to GLP-1 agonism, but it has not adapted to GIP agonism because it has never been exposed to pharmacological GIP activation before

Up to 92% of patients on tirzepatide achieved the ADA-recommended A1C target of less than 7%, compared to 81% on semaglutide

GIP, or glucose-dependent insulinotropic polypeptide, is a hormone that helps regulate blood glucose levels and supports fat cell storage

According to the FDA prescribing information, patients taking tirzepatide alongside insulin or sulfonylureas face particularly elevated hypoglycemia risk when consuming alcohol, as these medications do not have glucose-dependent action

If complete abstinence is not realistic, limit consumption to one to two drinks per week maximum

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