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Researchers investigating incretin-based compounds use Retatrutide as a reference molecule when comparing receptor selectivity and downstream signaling effects across the GLP-1/GIP/glucagon receptor family

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These findings support the utility of GLP-1 agonists for managing cardiometabolic risk in schizophrenia and may inform future guideline updates for long-term health outcomes

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The glucagon-like peptide-1 (GLP-1) receptor is a key regulator of glucose homeostasis and a drug target for type 2 diabetes but available GLP-1R agonists are suboptimal due to several side-effects

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