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Typical side effects include: Mild to moderate nausea, especially after larger or heavy meals A feeling of fullness or heavy stomach even after smaller meals Burping or changes in how your stomach feels after eating Constipation or, in some people, softer or more frequent stools Simple adjustments can often make these easier to handle: Eat more slowly and stop as soon as you feel comfortably full Choose lighter, less greasy meals on days when symptoms are stronger Drink water regularly throughout the day rather than in one large amount Go for gentle walks to help support digestion For many people, side effects decrease as their body adjusts and the dose increases gradually

The detailed background of the (patho)physiology of the incretin system and the history of the development of incretin-based glucose-lowering medications have recently been reviewed [15,16]

doi: 10.7150/thno.22565

In particular, it was suggested that GLP-1 may increase potassium-ATP currents, thereby increasing membrane potential of smooth muscle cells and preventing depolarization and contraction (Xiong et al., 2019)

Footnotes Table S1

Glucagon-like peptide-1 (GLP-1) receptor agonists aka the -tides, GLP analogs, incretin mimetics *The FDA has approved the use of -glutides to reduce the risk of major cardiovascular events (myocardial infarction, stroke, cardiovascular death) in adults with type 2 diabetes and established cardiovascular disease or multiple cardiovascular risk factors