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Nat Rev Cardiol 2019;16:457475

Chronic stress elevates cortisol levels, which can slow digestive motility, alter gut microbiome composition, and increase intestinal permeability

Knudsens work found that liraglutide was internalized by proopiomelanocortin (POMC)/cocaine- and amphetamine-regulated transcript (CART) neurons and indirectly inhibits neuropeptide Y (NPY) and agouti-related peptide (AgRP) neurons through Gamma Amino Butyric Acid (GABA) dependent signaling

Your clinician will screen for risks and contraindications

Other non-entero-pancreatic hormone-based pharmacotherapies such as bimagrumab and growth differentiation factor 15 (GDF-15) are also under investigation