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The GIP pathway improves fat oxidation and energy expenditure

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Important safety information: Orlistat (Alli, Xenical) is a weight-loss medication that reduces the amount of fat the body absorbs from food

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Side effects may vary depending on the dose and individual patient response

Common side effects (5% or more of patients) Nausea, diarrhea, vomiting, constipation, abdominal pain, decreased appetite, indigestion, injection site reactions Serious side effects (rare) Pancreatitis stop Zepbound and seek emergency care for severe, persistent abdominal pain radiating to the back Gallbladder disease upper right abdominal pain, fever, jaundice Severe allergic reactions facial swelling, throat tightening, difficulty breathing Acute kidney injury usually from dehydration due to prolonged vomiting or diarrhea Hypoglycemia most likely when combined with insulin or sulfonylureas in diabetic patients Increased resting heart rate Boxed warning: Tirzepatide caused thyroid C-cell tumors in animal studies