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GLP-1 receptor agonists have demonstrated significant weight loss results in clinical trials, with patients losing 15-22% of body weight over 68 weeks

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Conclusions GLP-1RA use was not associated with a decreased or increased risk of AF compared to DPP4i use

- - - A new Oxford meta-analysis (P04.009, EASO 2025) confirms what many clinicians have observed: stopping GLP-1 receptor agonists often leads to rapid and near-complete weight regain within 12 years