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(2022) "Tirzepatide Once Weekly for the Treatment of Obesity" New England Journal of Medicine, 387(3) 2

A breakthrough in long-term weight management has sparked demand for a new generation of weight loss drugs

Expression of dopaminergic receptors in the hypothalamus of lean and obese Zucker rats and food intake

And the receptor upregulation ensures maximum biological response to each GLP-1 molecule produced

While early research and anecdotal evidence suggest positive results, its long-term safety profile remains unclear due to limited human clinical trials

However, both medications affect the gastrointestinal system and require careful medical supervision when used concurrently