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GLP-1 receptor agonists and SGLT2 inhibitors in type 2 diabetes: Pleiotropic cardiometabolic effects and add-on value of a combined therapy

However, concerns have persisted regarding their potential association with pancreatitis

Risk of cardiovascular outcomes in patients with type 2 diabetes after addition of SGLT2 inhibitors versus sulfonylureas to baseline GLP-1RA therapy
Low blood pressure, or hypotension, is generally defined as a systolic blood pressure below 90 mmHg or diastolic pressure below 60 mmHg, though symptoms matter more than absolute numbers

Sources Lilly Retatrutide TRIUMPH-1 Phase 3 Topline Results FDA Concerns With Unapproved GLP-1 Drugs Used for Weight Loss FDA Wegovy Prescribing Information FDA Zepbound Prescribing Information Dr

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