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When we eat it kicks into gear, signaling the pancreas to release insulin, which helps regulate blood sugar levels

GLP-1 projections from NTS to NAc and VTA promote satiation and reduce food reward, while orexinergic projection from lateral hypothalamus to NTS suppresses satiation and increases food reward ( The paraventricular thalamic nucleus (PVT) neurons receive GLP-1 innervation from NTS and express GLP-1R ( Telencephalon Moderate density of GLP-1R is expressed in both the cell bodies and fibers of the NAc shell and core ( Morphological studies revealed that the neurons in the bed nucleus of the stria terminalis (BNST) express a high level of GLP-1R ( Inconsistent distribution patterns of GLP-1R in the hippocampus have been reported by different morphological studies ( in vivo electrophysiological recordings showed that juxtacellular application of the active fragment of GLP-1, GLP-1 (736) amide induces an increase and then a decrease of firing activity in the hippocampal CA1 neurons

Two types of diabetes drugs similarly effective in reducing heart and kidney disease

Once weekly subcutaneous injection

Do I still need metformin after starting a GLP-1 injection

Studies demonstrate this strategy can fuel more efficient fat loss, boost metabolic health, and reduce risks of chronic illnesses