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And for the pharmaceutical giants behind WEGOVY and ZEPBOUND, two of the best-selling drugs in modern history, the oral revolution is both their biggest opportunity and their greatest competitive threat

Insurance coverage is not a clinical difference

The journey from discovery of the GLP-1 hormone to treatments for diabetes and then obesity was a long and stuttering one, spanning more than four decades and involving hundreds of researchers across academia and the pharmaceutical industry

GLP-1 medications slow gastric emptying, which may create unpredictable metabolic feedback in patients with overactive thyroid function

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