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Description
Interestingly, obesity, for whose treatment GLP-1RAs are approved and validated 1,214 , is not classified under mental and behavioral disorders, and in some countries, such as the United Kingdom, it is not even formally recognized as a disease 246
The REWIND trial, targeting cardiovascular events in T2DM participants without previous cardiovascular history, found that dulaglutide reduced cardiovascular outcomes, and was well tolerated [61]

These therapies aim to enhance WL and improve metabolic outcomes by engaging multiple hormonal pathways, with preclinical and early-phase clinical trials supporting their potential as next-generation obesity treatments [1623]

Current Clinical Pharmacology

The findings were published in T he Journal of Clinical Endocrinology & Metabolism

In fact, albiglutide and dulaglutide had the fastest brain uptake, followed by DA5-CH, whereas tirzepatide had a slow brain uptake [35]
