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A slight increase was noted in active GLP-1 levels in the portal blood 120 min after the administration of TO

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First, tirzepatide is a dual agonist (targeting both GLP-1 and GIP receptors) and has proven results for weight loss and glycemic control

Similarly, in PD, early disease stages are characterized by oxidative stress and heightened proinflammatory responses that exacerbate nigrostriatal degeneration,111,112 with Proinflammatory mediators have also been identified in the substantia nigra of postmortem PD brains.113 Systemic inflammation plays a central role in the pathophysiology of hyperinsulinemia, insulin resistance, and T2DM