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( 10.2337/dbi21-0001) [DOI] [PMC free article] [PubMed] [Google Scholar] 89.Kaneko K, Fu Y, Lin HY, et al

A patient with genetic variants linked to higher hunger drive may benefit from remaining at the lower end of the calorie range (1,2001,400) or combining semaglutide with a complementary approach, while someone with lower baseline appetite might thrive at 1,6001,800 calories while still losing weight steadily

Hypoglycemia especially in patients with type 2 diabetes who are also taking insulin or sulfonylureas

Theoretically, L-carnitine may help a person work out longer and may stimulate greater amounts of fat loss as a result

For people with diabetes that usually means more frequent glucose checks for the first few weeks, so any hypoglycemia can be caught and medication doses adjusted

To bridge this gap, future research should prioritize studies designed to address the generalizability of TTE analyses in real-world settings