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Preclinical studies have confirmed that GIPRGLP1R coagonists improve several hallmarks of metabolic syndrome, such as obesity, hyperglycemia, and dyslipidemia

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In clinical trials, GLP-1 RAs were shown to significantly lower blood pressure (BP) in addition to HbA1c and body weight (BW), indicating the possibility as anti-hypertensive medication of type 2 DM individuals

Trail registration Study registered in clinicaltrials.org with the identifier NCT05535322.

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Learn about the Ozempic blindness lawsuit, including NAION and other vision problems, and read about the study linking semaglutide use to severe eye problems.