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STEP 10 [42] was the first phase 3 trial designed to assess the efficacy of semaglutide 2.4 mg specifically in individuals with obesity and prediabetes

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The medication reduces appetite by activating satiety receptors, slows gastric emptying to prolong fullness, and increases energy expenditure through glucagon receptor activation

PMID 19934256

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Higher protein intake is associated with better preservation of lean muscle mass, improved satiety, and sustained resting metabolic rate