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The biological significance isnt just about the peak levelits about sustained receptor occupancy

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Beyond diabetes and weight loss, GLP-1s have also been linked to improved heart health, with research showing they may lower the risk of cardiovascular disease, heart attack, and stroke

Brain GLP-1 and insulin sensitivity

for example, caution must be taken in the case of a patient suffering from gastroparesis since the activation of the GLP-1 receptor through the administration of an agonist leads to a decrease in gastric emptying, which induces an exacerbation of symptoms and even the discovery of the disease after drug intake

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