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In severe cases, dehydration or hypoglycemia (especially if used with certain drugs like insulin or sulfonylureas) can occur

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Glucagonlike peptide agonists: a prospective review

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Unfortunately, one death was reported, however, an independent panel ruled the death unrelated to semaglutide

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Researchers at the University of Virginia, supported by National Institutes of Health funding, found that oral small-molecule GLP-1 receptor agonists, including orforglipron, penetrate deeper into the brain than previously understood

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History of gastrointestinal disorders (e.g., gastroparesis or inflammatory bowel disease), as semaglutide may slow gastric emptying and worsen these diseases

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