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Evaluation of an [(18)F]AlF-NOTA Analog of Exendin-4 for Imaging of GLP-1 Receptor in Insulinoma

rosuvastatin less CYP-dependent) Excretion: Bile and feces Clinical Uses Hypercholesterolemia Familial hypercholesterolemia Atherosclerotic cardiovascular disease (ASCVD) prevention Post-myocardial infarction / stroke risk reduction Adverse Effects Muscle-related: Myalgia, myopathy, rhabdomyolysis (rare, serious) Liver enzyme elevation monitor LFTs GI upset: nausea, abdominal pain Contraindications: Active liver disease, pregnancy, breastfeeding Drug Interactions CYP3A4 inhibitors (e.g., certain antifungals, macrolides) risk of myopathy Avoid grapefruit juice (CYP3A4 inhibition for simvastatin, atorvastatin) Main effect: LDL cholesterol Secondary effect: stabilize plaques, anti-inflammatory Most potent LDL-lowering statins: Rosuvastatin, Atorvastatin Monitor: LFTs, CK if muscle symptoms appear Avoid in pregnancy Mnemonic for Statin Adverse Effects: HMG H for Hepatic, M for Muscle, G for GI To view or add a comment, sign in Glibenclamide (Glyburide) Glibenclamide is a sulfonylurea antidiabetic drug used to treat type 2 diabetes mellitus

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