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In conclusion, GLP-1 RAs are an intriguing multitarget treatment option for people with NDs, and future research should focus on optimizing treatment for clinical trials, evolved agonists that can penetrate the central nervous system (CNS), and combination therapies.

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Female GLP-1RA users showed increased HSV risk (HR=1.51), and poorly controlled patients (HbA1c7%) had higher HSV risks (HR=1.195)

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