no weight loss tirzepatide In adults with obesity but not diabetes, leads to significantly greater than semaglutide over 72 weeks, and nearly double the patients on tirzepatide meet the 25% weight-loss target. http://ms.spr.ly/6183SkuIL Semaglutide Or Tirzepatide: Which Weight
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(2021, October 13)

Plain Language Summary Many people with type 2 diabetes mellitus (T2DM) do not achieve and maintain glycaemic and weight management goals using currently available treatments

Diabetes Obes Metab 2017;19(7): 1024e31

The short answer is, sometimes

Tirzepatide bypasses this issue by heavily engaging GIP receptors, which are encoded by a separate gene (GIPR)