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Evidence is emerging that glucagon-like peptide-1 (GLP-1) receptor agonists have anti-inflammatory and chondroprotective properties independent of their effects on weight loss

Glucagon-like peptide-1 (GLP-1) is an incretin peptide hormone mainly secreted by enteroendocrine intestinal L-cells

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Injection-site reactions and worsening of pre-existing diabetic retinopathy are also relevant clinical concerns

It has been studied in human clinical trials and shown to support metabolic balance, healthy blood glucose regulation, inflammation management, and improved insulin function

However, owing to their peptide-based composition, GLP-1RAs have traditionally required injectable administration, which undermines patient adherence, convenience, and long-term accessibility