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As GLP-1Rs are expressed in multiple brain regions, and GLP-1RAs such as liraglutide and lixisenatide can penetrate the blood-brain barrier, liraglutide and exendin-4 can be vagus-dependent or independent in the suppression of the food intake (176)

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3) No guideline recommends oral corticosteroids, benzodiazepines, anticonvulsants, or antibiotics for acute or chronic non-specific LBP