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Exogenous leptin administration is associated with a suppression of food intake, a reduction in body weight, and an upregulation of uncoupling protein 1 (UCP1) expression in adipose tissue depots, all of which have been suggested to require a fully functioning histaminergic system (79, 80, 92, 133)

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J.CapehornM.CharpentierG.DottaF.HenkelE.LingvayI.et al (2018)

The following section extends this analysis to peptide systems that mediate bonemusclefat crosstalk, where the endocrine functions of traditionally structural tissues challenge conventional models of metabolic regulation