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Unlike earlier GLP-1 receptor agonists like semaglutide (Ozempic/Wegovy) that target a single hormone pathway, or tirzepatide (Mounjaro/Zepbound) that targets two, retatrutide activates three distinct metabolic receptors : GIP, GLP-1, and glucagon

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24 Cosmetics/Beauty and Wellness Industry: The psychological impact of the change could have a similar impact on the cosmetic/beauty industry, with a Piper Sandler analyst recently highlighting that the broader awareness for appearance could be a tailwind. 25 5: Reduction in Average Weight A reduction in average weight across the population could also have widespread impact across several industries

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Weight loss across this period was stratified by quartiles of engagement (Quartiles of average total app opens at 40 weeks: Q1 = 244.7 , Q4 = 2,162.2)