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The downsides are obvious

For a patient weighing 220 pounds, semaglutide might produce 22-33 pounds of weight loss, while tirzepatide might achieve 33-48 pounds

Arch Gynecol Obstet (2015) 292(4):74956

Another area of uncertainty involves side effects, as users' perceptions of symptoms such as nausea or fatigue may vary widely and may even be interpreted as markers of treatment efficacy

In the present study, we did not observe any effect of adrenergic blockers on the GLP-1-elicited increase in heart rate in pigs