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The timing of heartburn varies by individual

For the bigger response window behind early stomach symptoms and later body-weight endpoints, see our how long retatrutide takes to work timeline

Glucose-dependent Insulinotropic Peptide Glucose-dependent Insulinotropic Peptide (GIP) is a 42-amino acid peptide hormone produced by K cells located primarily in the proximal small intestine (44)

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Nielsen LH, Lkkegaard E, Andreasen AH, Keiding N