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Psychiatry 26, 43944408

And when side effects persist beyond the typical 4-6 week adjustment period, switching to an alternative with a different receptor binding profile or mechanism of action often resolves the issue entirely

But the clinical stakes extend considerably further

People taking GLP-1 receptor agonists may become dehydrated from vomiting or diarrhea, causing kidney problems

383,384 Importantly, the activation of AMPK reduces the expression of phosphoglycerate mutase 5 (PGAM5), which plays a promotive role in cell necrosis by contributing to mitochondrial dysfunction and the production of reactive oxygen species (ROS)
