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Insert the needle at 45-90 degrees

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Orforglipron, Eli Lilly oral GLP-1 candidate, sidesteps the entire oral peptide delivery problem by not being a peptide

The SURMOUNT-4 trial demonstrated that when participants switched from tirzepatide to placebo, they regained approximately 14% of their body weight over 52 weeks

An ongoing assessment of comfort, weight changes, and any adverse effects should guide dosage decisions

We were careful to exclude potential confounding factors like sedation, anhedonia, and malaise since tirzepatide did not affect baseline locomotor activity, dopamine levels per se, or kaolin consumption