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A 2024 meta-analysis of 17 studies found that people with epilepsy were 28% more likely to have obesity compared to the general population

Semaglutide use in patients using insulin has not been evaluated

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During the shortage, clinicians are also required to: Only prescribe GLP-1 RAs for their licensed indication Review the need for prescribing a GLP-1 RA agent and stop treatment if no longer required due to not achieving desired clinical effect as per NICE CG28 Avoid switching between brands of GLP-1 RAs, including between injectable and oral forms Where a higher dose preparation of GLP-1 RA is not available, do not substitute by doubling up a lower dose preparation Where GLP-1 RA therapy is not available, proactively identify patients established on the affected preparation and consider prioritising for review based on the criteria below

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This raises the minimum risk-adjusted value each programme needs to generate to counteract their cost to develop, meaning portfolios with many lower forecast value assets face disproportionate pressure unless they are clearly differentiated or strategically essential