when did glp 1 agonists come out Timeline of GLP-1 discovery and clinical development. (a) Key events in PDB-101: Molecule of the Month:
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In a landmark development, liraglutide (Saxenda) was approved in 2020 for use in adolescents aged 12-17 years with a body weight above 60 kg and an initial BMI corresponding to 30 kg/m for adults [17]

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Every compound in this class, from semaglutide to tirzepatide to these newer agents, causes nausea, vomiting, and diarrhea to some degree

Kim S-J, Nian C, Doudet DJ, McIntosh CH

The 12mg group showed the most pronounced effects across all measured endpoints, but the 8mg group demonstrated a favorable balance between efficacy and tolerability
