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Significance statement ![Figure][1] ### Competing Interest Statement The authors have declared no competing interest

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While a number of mechanisms including vascular, myocardial, renal, and central nervous system pathways have been suggested in animal studies, these mechanistic pathways have not been sufficiently detailed in humans and it is unclear if the same pathways are operational

Mechanism: Activates antioxidant pathways and supports mitochondrial function at the cellular level

The correct point is just under the index finger and between the two central tendons

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