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Retatrutide is called a triple agonist because it activates three hormone receptors: GLP-1, GIP and glucagon

Clinical observations, while valuable, lack the controls necessary for confident conclusions

Between 1969 and 1971, work by John Brown and Raymond Pederson, together with the peptide chemistry expertise of Erik Jorpes and Viktor Mutt [67], led to the identification of the gastric inhibitory polypeptide (GIP), a 42-amino acid polypeptide that was named based on its potency to suppress gastric motility and gastric acid secretion [[68], [69], [70]]

However, their use presents specific challenges when obesity is coexisting with eating disorders

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