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There is a discrepancy between the magnitude of improvement in glycemic control and the weight loss, cardiovascular, and renal benefits obtained in large clinical trials

10.1210/clinem/dgae719 [DOI] [PMC free article] [PubMed] [Google Scholar] 19.Horowitz M, Rayner CK, Marathe CS, Wu T, Jones KL (2020) Glucagon-like peptide-1 receptor agonists and the appropriate measurement of gastric emptying

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The biological evaluation of the newly synthesized chemical agents demonstrated that molecule 63 possesses the most potent enzyme inhibition activity, with an IC 50 of 17.7 M (Figure 7)