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Primary Handling Editor: Jennifer Sargent, in collaboration with the Nature Medicine team

Protein becomes critically important during GLP-1 therapy because rapid weight lossparticularly when exceeding 12 pounds per weekincreases the risk of losing muscle mass alongside fat tissue

The USP Chapter 795 (for non-sterile preparations) and USP Chapter 797 (for sterile preparations like injectable semaglutide) provide the framework pharmacies use to determine these dates

By contrast, substantial transcriptional alterations were not induced by the conjugate in the nucleus accumbens (Extended Data Fig

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