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Why pharmacy-grads love this one: Some people are born with natural loss-of-function PCSK9 mutations

Discontinuation due to side effects ran from about 5% at 5 mg to about 10% at 15 mg

You shouldnt take Ozempic, Wegovy, or other GLP-1 medications if you have any of these pre-existing conditions or circumstances: Personal or family history of medullary thyroid carcinoma (MTC) History of Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Type 1 diabetes Severe gastrointestinal disorders (like gastroparesis or severe IBS) Pancreatitis (current or past) Gallbladder disease or history of gallstones Liver or kidney disease that isnt well managed Pregnancy or breastfeeding Medication alone wont fix all your symptoms

This significantly increases the risk of adverse effects including nausea, vomiting, and hypoglycaemia

Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels

(1985) Human distribution and release of a putative new gut hormone, peptide YY