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Description
Clinical trial data have produced mixed findings that require careful interpretation

2014 Jun;51(3):491497
Where it works: Liver: Increases hepatic glucose production and fat oxidation (when carbs are low) Adipose tissue: Stimulates lipolysis (breakdown of stored fat into free fatty acids) Brown adipose tissue: Activates thermogenesis (heat production from burning fat) Muscle: May increase fat oxidation during exercise Weight loss contribution: The glucagon component appears to add an additional 2-3% weight loss beyond the GLP-1/GIP combination (24% vs 22% for tirzepatide)
An LMN is a document written by your healthcare provider that explains why a specific treatment is necessary for your health

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14,15 Another meta-analysis of 93 clinical trials showed that GLP-1 RAs increased the risk of early-stage DR compared with placebo, with this effect being driven by albiglutide in particular
