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Real-world data from a 2025 study in Diabetes, Obesity and Metabolism which looked at actual clinical patients rather than trial participants showed tirzepatide patients lost 5.3% of body weight over six months compared to 2.7% with semaglutide

doi: 10.1016/S0731-7085(02)00278-9, PMID: [DOI] [PubMed] [Google Scholar] Hendin H

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I would [advise] owners, both for the benefit of their pockets, and possibly for the benefit of their pets, to try modifying their dogs diet and exercise regime first, because I think we know that that can be safe and effective if done well, she said

For researchers who use pharmaceutical GLP-1 therapies as their primary intervention, many of these supplements serve as useful adjuncts