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Unlike insulin-boosting medications that worsen the excess insulin problem, semaglutide reduces the amount of insulin the body needs to maintain stable blood sugar

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Clinicians should conduct thorough baseline assessments including detailed medical and family histories before initiating semaglutide

Some patients benefit from continuing microdose GLP-1 therapy or transitioning to alternative compounds if weight regain becomes evident

doi: 10.1002/oby.20340
